Colon Cancer Treatment

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Colon Cancer Treatment

Leucovorin 500 mg/m 2 given as a 2-h infusion and repeated weekly for 6 wk plus 5-fluorouracil (5-FU) 500 mg/m 2 given as a bolus 1 h after the start of leucovorin and repeated six times weekly; every 8 wk for four cycles

Common regimens include 5-FU and leucovorin with or without oxaliplatin or capecitabine, as follows

mFOLFOX6: Oxaliplatin 85 mg/m 2 IV over 2 h on day 1 plus leucovorin 400 mg/m 2 IV over 2 h on day 1 plus 5-FU 400 mg/m 2 IV bolus on day 1, then 1200 mg/m 2/day for 2 d continuous infusion; repeat every 2 wk